These ailments are caused by the presence of varied types of crystals in just joints. Uric acid crystals give rise to gout, although calcium pyrophosphate crystals result in pseudogout. The crystals are responsible for pain, swelling and inflammation of joints, including the knee, ankle and foot joints. Advancement of Osteoarthritis: https://www.theorthopaedicandpainpractice.com/what-is-an-anterior-cruciate-ligament-acl-injury/