Human APPL1 and APPL2 are homologous RAB5 effectors whose binding partners include a diverse set of transmembrane receptors. signaling proteins. and phosphoinositides. APPL proteins associate dynamically with endosomal membranes and are proposed to function in endosome-mediated signaling pathways linking the cell surface to the cell nucleus. https://www.jmannino.com/best-catch-University-of-Miami-The-U-iPhone-14-Plus-Clear-Case-p36265-quick-deal/