Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators with the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have identified recurrent mutations in genes regulating tumor cell-microenvironment interactions, whic... https://tuckert986esg2.wonderkingwiki.com/user